cons of retatrutide Diagram showing the mechanism action of Pros and Cons of Retatrutide:

While clinical trials show adults on the highest dose of Zepbound lose an average of 22.5% of their body weight after 72 weeks (when paired with diet and exercise), recent Phase 3 trial data (from the TRIUMPH-1 study released in May 2026) shows even better results

The phase 2 study to evaluate the efficacy, safety and tolerability of maridebart cafraglutide is currently ongoing (ClinicalTrials.gov number, NCT05669599)

Diabetes Obes Metab (2020) 22(8):140616

This effect occurs through weight loss, improved insulin sensitivity, reduced hepatic VLDL production, and decreased postprandial lipemia, though individual responses vary

When to Call Your Doctor: Red Flags Seek Immediate Medical Attention Persistent vomiting (can't keep down liquids for 24+ hours) Severe abdominal pain (especially upper right could be gallbladder) Signs of pancreatitis (severe upper abdominal pain radiating to back) Severe allergic reaction (difficulty breathing, swelling of face/throat) Vision changes Significant dehydration (unable to urinate, severe dizziness) Call Doctor Soon (Not Emergency) Persistent nausea lasting beyond first 2 weeks at stable dose Dysesthesia with pain or weakness Unexplained lump in neck (thyroid concern) Hypoglycemia episodes if diabetic Persistent diarrhea leading to dehydration Normal, Don't Worry Mild nausea in first few days after dose increase Reduced appetite (desired effect!) Mild injection site reactions (redness, swelling) Mild dysesthesia (tingling without pain) Occasional loose stools Fatigue during rapid weight loss phase Practical Tips: Maximizing Benefits, Minimizing Side Effects The Slow Titration Principle TRIUMPH-4 and TRIUMPH-1 both used a 1216 week titration schedule (2mg 4mg 6mg 9mg 12mg)

In the SURMOUNT-1 trial, patients lost an average of 22.5% of body weight over 72 weeks