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Conversely, serine deprivation triggers cellular stress and adaptive metabolic remodeling, and subsequently suppresses tumor progression ( de novo serine synthesis pathway has emerged as a central focus in the field of cancer metabolism research ( 3 Core roles of the de novo serine synthesis pathway in malignant tumors The serine synthesis pathway exerts multiple critical functions in cancer cells

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Most strikingly, late-life-initiated intermittent treatmentstarted at 23.5 months, the murine equivalent of late human lifeincreased physical capacity and healthspan

Polimanti R, Piacentini S, Lazzarin N, Re MA, Manfellotto D, Fuciarelli M