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Age-related changes in renal function, hepatic metabolism, and tissue perfusion theoretically could influence peptide clearance and distribution, though no studies have systematically examined age effects
Human data is extremely limited: ~30 subjects across all published studies
doi:10.1111/jpi.12172
Urology 133 , 7883 (2019)
They work by delivering a concentrated dose of B12, typically in the form of hydroxocobalamin, directly into the muscle
This approach maintains more consistent peptide levels throughout the day and may provide advantages for individuals using doses at the higher end of the range (450-500mcg daily)
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