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Originally identified by Loren Pickart in human plasma, GHK-Cu has been the subject of extensive cellular biology and biochemical research literature for over five decades, with research contexts examining tissue biology, cellular signaling pathways, copper-binding peptide chemistry, and extracellular matrix research

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This makes light protection and oxygen-limited storage somewhat more important for TB-500 than for BPC-157

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BV is used in wound dressing alongside polyvinyl alcohol and chitosan