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Fatty Liver Disease Expert Committee

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Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria

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This regulated necrotic cell death is activated in response to Fas/FasL signaling, CD59 ligation combined with pore formation, mediated by ROS, ceramide, and advanced glycation end products (AGEs) [28]

Although both dysregulated hepatic glutathione homeostasis and TNF overproduction are critically involved in the development of NAFLD, whether they can be synergistically implicated in hepatocyte death remains to be clearly defined