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This combination of effects can lead to significant weight loss to the tune of 15% to 21% of your starting body weight, on average, according to studies

reported in approximately 4060% of participants in higher-dose groups Vomiting reported in approximately 2030% of participants at higher doses Diarrhoea Constipation Decreased appetite (which, whilst contributing to weight loss, can also be uncomfortable) The majority of gastrointestinal events were mild to moderate in severity and tended to diminish over time as participants adjusted to the medication

Gastrointestinal side effects like nausea, fatigue, and digestive discomfort can compound into feelings of irritability or low mood

Clinical Pharmacokinetics, 56 ,

However, **weight loss plateaus quickly** and usually rebounds if not paired with long-term lifestyle changes

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