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However, the review stresses that direct attribution of these effects to GLP-1R-mediated anti-inflammatory pathways remains to be conclusively demonstrated

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but this was not driven by any single study, again adding to the argument that between subjects' variation may contribute to the dispersion of the mean effect in MRS studies of ACC GSH

The metabolism and clearance of both components may be affected by significant liver disease, and patients with severe hepatic impairment should be monitored closely if treatment is deemed necessary