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Isakovic et al., metformin led to significant induction of caspase-dependent apoptosis in C6 rat glioma cells, associated with c-Jun N-terminal kinase (JNK) activation, mitochondrial depolarization, and oxidative stress (49)

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As these fats are finally transported across the inner mitochondrial membrane, the mitochondria are resupplied with the substrate necessary to resume beta-oxidation and generate robust amounts of ATP

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Obesity and diabetes associated PC stem cells Studies are suggesting that tumor initiation, progression, and resistance to chemotherapy is due to the presence of a small subset of a cell population within the tumor called cancer stem cells [180,181,182]