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Since -Klotho is not expressed in pituitary adenoma, elevated sKlotho levels are most likely due to increased renal -Klotho and consecutively, enhanced cleavage of its extracellular domain as the main source of sKlotho ( vide supra ) [112, 113]

Tryptophan oxidation products (kynurenine, oxindolylalanine) are specific impurities to monitor

LB medium was prepared with the appropriate antibiotic