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While GLP-1 RA prevalence among non-diabetic adults held steady at 0.1% from 2018-2021, it quadrupled to 0.4% in 2022 alone

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This tri-receptor activity is what fundamentally distinguishes Retatrutide from all preceding incretin research compounds, including dual agonists like Tirzepatide (GLP-1R/GIPR) and single agonists like Semaglutide (GLP-1R only), and is the basis for its position at the leading edge of metabolic peptide research