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These cells strongly respond to the well-known hormone receptor drug agonists Semaglutide, Orforglipron, Tirzepatide, and Retatrutide (see figures)

For repeat-dose studies, variability in quantitative endpoints approached 0.5 log units

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Aroda, Efficacy and Safety of Once-Weekly Semaglutide Versus Exenatide ER in Subjects With Type 2 Diabetes (SUSTAIN 3): A 56-Week, Open-Label, Randomized Clinical Trial

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