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These effects were noted in obese mice and beta(3)-adrenergic receptor knock-out mice, suggesting that AOD-9604s actions are not mediated directly through the beta(3)-adrenergic receptor, a known facilitator of lipolysis

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Teduglutides single AlaGly substitution at position 2 removes the DPP-4 cleavage site [7] , extending the half-life to roughly 2 hours in healthy subjects and about 1.3 hours in short bowel syndrome , with 88% subcutaneous bioavailability [1]