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Blood 134 , 3002 (2019)

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Mean weight change was 5.0% (SE 0.3%) with naltrexonebupropion versus 1.8% (SE 0.4%) in the placebo group (estimated treatment difference 3.2%).38 Change in HbA 1c was superior with naltrexonebupropion (0.6%) versus placebo (0.1%) (estimated treatment difference 0.5%)

A review of practical issues on the use of glucagon-like peptide-1 receptor agonists for the management of type 2 diabetes

While the body produces GLP-1 naturally, individuals with type 2 diabetes or obesity may have impaired GLP-1 responses, which makes it harder for them to control blood sugar and manage their weight