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Average weight loss at six months is approximately 12 to 15% of starting body weight with semaglutide 2.4mg and 15 to 19% with tirzepatide at higher doses

Despite suggestions that the gastric emptying effects are greatest in the first 12 weeks and that the effect wanes weeks later, there is no certainty, and the impact on a given patient might be variable

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The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest

However, these trials were done with older GLP-1 drugs