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These products have not been evaluated or approved by the FDA, EMA, or Health Canada

Adv Nutr 6(4):474486 Acknowledgements The authors acknowledge the use of advanced research tools for literature search and data synthesis in the preparation of this comprehensive review

However, the half-life of GLP-1 is too short at 1 to 2 minutes, making it difficult to use as a drug [21]

While GLP-1 RAs may cause some side effects, most commonly diarrhea, vomiting, and nausea, these range from mild to moderate and can be lessened by reducing the dose

Structurally, GLP-RTis derived from the glucagon peptide backbone and consists of a 39-amino-acid sequence modified with targeted substitutions that enhance resistance to enzymatic degradation while preserving receptor affinity

The start of a new year typically generates a spike in interest in personal health and wellness goals