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While single-dose or short-term studies may demonstrate acceptable safety, the long-term consequences of daily or weekly tissue penetration over years of chronic therapy remain to be characterized

Duffy K, Grossman D

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egtA deletion was also successfully achieved in A

4648 Mechanistically, TMAO may induce T2DM by inducing pancreatic -cell dysfunction, chronic inflammation, oxidative stress, and disrupting glucose and lipid homeostasis

Pero las expectativas deben ser realistas: el seguimiento y la vigilancia mdica son esenciales para maximizar los resultados y ajustar el tratamiento segn la respuesta individual