Based on results reported here, PC cells with VRK2 high expression can tolerate GSH inhibition because of its sufficient antioxidant capability which reflected by low basal level of ROS and high basal level of GSH
Sources: Proksch, Ehrhardt, et al
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Understanding these predispositions can support a more informed conversation with your provider about whether ongoing treatment, alternative compounded options, or tapering strategies align with your metabolic profile
This lends itself to modification of behavior
The most commonly reported side effects were gastrointestinal, including nausea, vomiting, diarrhoea, and constipation, which were generally mild to moderate and most frequent during the dose-escalation phase