Their role in both the regulation of metabolic pathways and as signaling molecules makes them crucial in understanding numerous diseases, particularly metabolic disorders, cardiovascular conditions, and neurological diseases
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Additionally, the absence of microbiota, or the presence of broad-spectrum antibiotic-induced dysbiosis, triggered the NOD-like receptor family pyrin domain (PYD)-containing 6 (NLRP6)/Caspase 11 (Casp11) inflammasome-mediated pathway and subsequent loss of iEANs and enteric neuropathy (Muller et al., 2020a)
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References to specific molecules, trials, and effect sizes reflect the published literature and trade reporting available as of April 2026 and may change as additional data publishes.
This can create a frustrating cycle where the physical sensation fuels more worry, which in turn makes the palpitations even worse
