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Los efectos sobre la sensibilidad a la insulina y la produccin heptica de glucosa estn principalmente mediados por la prdida de peso

In the STEP 1 trial extension (Wilding and colleagues, 2022), participants who stopped semaglutide regained about two-thirds of the weight they had lost within roughly a year, and many cardiometabolic improvements moved back toward baseline

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doi:10.1186/1471-2458-9-88 3

Some people experience mild side effects such as nausea, constipation, or fatigue, especially during the first few weeks

doi:10.1016/j.cardfail.2014.11.006 81