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Early mitochondrial calcium defects in Huntingtons disease are a direct effect of polyglutamines

A high level of R-2-HG is sufficient to cause leukemia to arise from hematopoietic cells by maintaining their dedifferentiation and proliferation activities 116

Translationally controlled tumour protein (TCTP) is a highly conserved and widely expressed protein, and in a recent study, overexpression of TCTP in mouse oocytes was shown to reverse age-associated telomere shortening by increasing telomerase activity [75]

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