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If you have an underlying health condition like kidney disease, or if you take medication that interferes with B6 metabolism or absorption (such as oral contraceptives, hypertension drugs like hydralazine, and others), ask your doctor about appropriate supplement dosing

Nonetheless, cycling usage (e.g., eight weeks on, four weeks off) and medical supervision are recommended, especially for those with pre-existing kidney or liver conditions

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2011 Aug;94(8):3739-46.

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