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2.5.2 ESAIC Guidelines: The ESAIC has published new guidelines on the preoperative assessment of adults undergoing elective noncardiac surgery, dedicating a full section to the perioperative management of GLP1 RAs and SGLT2 inhibitors [3] : "R12.1: When a GLP-1 agonist is prescribed as a weekly injection and considering the long half-life of GLP-1 agonists, we recommend pausing GLP-1 agonists at least 1 week before a scheduled procedure requiring sedation/anaesthesia

Furthermore, AZA (and its metabolites) can induce apoptosis of T cells through cluster of differentiation-28 (CD28) co-stimulation, mediated by a specific binding of azathioprine-generated 6-thioguanine triphosphate to Ras-related C3 botulinum toxin substrate 1 (Rac1) instead of GTP, converting a co-stimulatory into an apoptotic signal

BruyreOCooperCPelletierJPBrancoJLuisa BrandiMGuilleminFet al

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Orthostatic Hypotension: JACC state-of-the-art review