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Leptin, an adipocyte-derived hormone known to regulate energy homeostasis, acts in the brain to control energy and glucose metabolism [71]

Semaglutide is a long-acting GLP-1 receptor agonist that mimics the action of incretin hormones

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However, the broader systematic review across all presentations

When semaglutide slows your digestive process, your levothyroxine may not absorb as efficiently, potentially lowering your thyroid hormone levels even though you're taking the same dose