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In recent years, small fish such as medakas and zebrafish, have gained attention as new model organisms
ERBB2 (HER2) may contribute to decreased IGF-1R expression during mammary tumorigenesis [119]
Tu et al., 2019)
Regulatory Framework: Key FDA Guidance Documents for Nasal Sprays The foundation of nasal spray testing requirements in the United States is established by two primary FDA guidance documents, both from the Center for Drug Evaluation and Research (CDER): FDA CDER 2002 Nasal Spray and Inhalation Solution, Suspension and Spray Drug Products Chemistry, Manufacturing and Controls Documentation (CMC Guidance): Defines the CMC documentation requirements for new drug applications (NDAs) and abbreviated new drug applications (ANDAs) involving nasal spray and inhalation drug products
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