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Measurements should be taken at consistent times, after 5 minutes of rest, using a validated upper-arm cuff device (not wrist or finger devices)

This promotes lactylation of vacuolar protein sorting 34 (VPS34), which in turn amplifies autophagic flux and endolysosomal trafficking (15)

It reduces the production of reactive oxygen species (ROS) and decreases the expression of NADPH oxidase 2 (NOX2), NOX4, and ICAM-1 in human umbilical vein endothelial cells (HUVECs)

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Acknowledgements Editorial Staff Elizabeth Jean Betsch, ELS Amy Zierler, BA Medical Information Services Corinne Holubowich, BEd, MLIS Kellee Kaulback, BA(H), MISt Clinical Expert Advisory Panel: Appropriate Utilization of Vitamin B12 Testing for Neurocognitive-Based Indications