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The standard titration schedule spans 16 weeks, starting with 0.25 mg once weekly, then progressing to 0.5 mg, 1.0 mg, 1.7 mg, and finally 2.4 mg as the maintenance dose

Thus, high total IGF-I levels in CKD is inadequate in suppressing the increased GH levels because of the lower IGF-I bioactivity resulting in the lack of IGF-I feedback on pituitary GH secretion (75, 77) ( Table 1

It was soon followed by Wegovy, the higher-dose version approved specifically for obesity

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