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The study found that FOXO4 localizes predominantly in the cytoplasm of Leydig cells in young mice but translocates to the nucleus in aged animals the same FOXO4-p53 sequestration pattern seen in other senescent cell types
ROS dysregulation in inflammation ROS act as both effectors and amplifiers in chronic inflammation
113,114,115,116,117 The Aldehyde dehydrogenase 1 isoform A3 (ALDH1A3), normally not expressed in mature islets, is activated in diabetic patients, which damages characterization of cells, leads to dedifferentiation and impairs secretory function
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