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Later in the review, we look for supporting evidence for metabolic pathway dysfunction, identified by serum and plasma metabolomics, by examining proteomics analysis of biological material and whole patient imaging studies

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Because NNMT occupies a central position within nicotinamide methylation pathways, it has become an important target for investigations involving enzyme regulation, methyl-donor utilization, cofactor-associated signaling networks, and methyltransferase pharmacology

Funding This research was supported by the Ministry of Science and Technology of Taiwan (MOST 108-2221-E-002-163, MOST 109-2221-E-002-083) and National Taiwan University Hospital (107-EDN11, 108-N4406, 108EDN02, 109-O20, 109-S4579, 109-EDN11)