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In the liver , it binds to toxins, alcohol byproducts, heavy metals, and environmental chemicals so the body can process and clear them safely

Once in the cytosol, Glu and Cys are combined into the dipeptide -glutamylcysteine (-GC) by the enzymatic activity of glutamatecysteine ligase (GCL), which requires ATP and Mg 2+ as co-substrates (Figure 2A) [15,16,17]

Doxorubicin, one of the most important chemotherapy drugs that functions by blocking topo-isomerase 2 is a quinone containing compound

This enzyme has the task of combining the amino acids glutamate and cysteine to form Glyteine, which is eventually needed to produce glutathione by the next enzyme GS

Journal of Alternative and Complementary Medicine, 17 (9), 827-833

Glutathione acts as a direct antioxidant