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An experiment with hepatic stellate cells, which are key in the development of liver fibrosis, revealed that EGCG can regulate the growth and structure of these cells, such that EGCG may turn out to be a therapeutic agent for liver fibrosis (Higashi, Kohjima 2005)

Stopping often reverses benefits

"We now have more than two years of experience using these medicines for weight loss, and what we're seeing is that, in some cases, one drug is better, it has fewer side effects, and perhaps greater efficacy than the other," Aronne said

Mechanistic Studies Subsequent research has explored the mechanisms by which NNMT regulates metabolism, with studies demonstrating that NNMT activity reduces cellular NAD+ availability, affects SAM-dependent methylation reactions, modulates sirtuin activity, and influences adipocyte differentiation and function

Nature Reviews Molecular Cell Biology, 19, 638653

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