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A review of pivotal clinical trials for semaglutide (STEP, SUSTAIN), dulaglutide (REWIND), liraglutide (LEADER), and tirzepatide (SURPASS, SURMOUNT) does not identify muscle cramps as occurring at significantly higher rates compared to placebo groups
According to GoodRx, a company that operates a telemedicine platform that tracks drug prices and provides drug coupons for discounts, the number of people with no commercial insurance coverage for Zepbound (tirzepatide) increased by over 180% in 2025
Deng J, Gu S, Shao H, Dong H, Zou D, Shi L
doi: 10.1172/jci.insight.92002 138 MikeL
Eur J Pharmacol 966:176341
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