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[37] [38] The evolution of NiSOD is currently predicted to have occurred around the time of the GOE when a decrease in aquatic bioavailability of Fe took place

The molecular mediators identified from these studies could serve as potential biomarkers

While Wu et al (202) recently addressed lactate-regulated ferroptosis in cancer contexts and acknowledged the context-dependent nature of this phenomenon, their analysis did not elucidate the mechanistic determinants underlying this differential regulation

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