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Structural Comparison with Tirzepatide# The structural relationship between retatrutide and tirzepatide warrants detailed comparison, as both are multi-receptor incretin agonists developed by Eli Lilly: The most pharmacologically consequential structural difference is the engineering of glucagon receptor agonism into retatrutide

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It should be noted that the cerebral cortex and the cerebellum interestingly lack the expression of the GLP-1R in rat models [51]

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