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In addition, SARS-CoV-2 infection leads to the release of pro-angiogenic factors, such as vascular endothelial growth factor A (VEGF-A) (23)

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It is worth mentioning that ebselen does not contribute to the bioavailable selenium pool required for the biosynthesis of selenoproteins including seleno-GPxs and therefore its ability to detoxify hydroperoxides under cellular conditions can exclusively be attributed to GPx mimicking activity [77, 79]