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The secretory pathway, including the endoplasmic reticulum, the Golgi and the endosomal system play central roles in this trafficking (Figure 1)

Additionally, Mounjaro , one of the newer diabetes drugs, which was approved in May 2022 and has a unique dual mechanism of action (it activates the GLP-1 hormone as well as another hormone called the glucose-dependent insulinotropic polypeptide or GIP, both helping to improve blood sugar) may be even more effective than semaglutide in reducing weight

They are pathway-level markers that do not predict response to a specific drug, but they add context that a prescription alone, from any GLP-1 program, does not capture

Availability of data and materials Data sharing is not applicable to this article as no datasets were generated or analyzed during the current work

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