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These findings point out the necessity to differentiate between adaptive and maladaptive cortisol responses

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Due to the highly similar coordination chemical structure of divalent hydrated platinum ions (Pt 2 ) and copper ions (Cu 2 ), Pt 2 can competitively bind to the methionine binding sites of CTR1 and enter renal tubular epithelial cells through CTR1-mediated endocytosis (Arnesano et al