The most modulated genes found through the network approach were SIRT3, FOXO1, and PPARGC1A, these proteins were also found to have the highest docking results, several studies have reported the role of these proteins in the modulation of ROS and oxidative stress via mitochondria, as ROS and oxidative stress have been reported to alter various cellular signaling pathways and cause neuronal death
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Am J Physiol Gastrointest Liver Physiol 2010;298:G364-G374
Specific alterations in the expression of the urea cycle enzymes in different cancers profoundly affect nitrogen-containing macromolecules, such as nucleotides and proteins, which are associated with tumor initiation and progression, even immunotherapy response (Lee et al., 2018)
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