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Activities were measured in the presence of glycylglycine as the -glutamyl acceptor substrate
The third EPS secretion mechanism, which appears to be used by bacteria for the secretion of many high-molecular-weight polysaccharide moieties, such as cellulose 45 , alginate 46 , and poly--D- N -acetylglucosamine (PNAG 47 ), is called the synthase-dependent pathway 7 , referring to the fact that a cytoplasmic membrane-embedded glycosyl transferase simultaneously facilitates polymerization and trans-membrane translocation 48
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Exenatide, and in particular its extended-release (ER) formulation, is the GLP-1 receptor agonist with the broadest clinical evidence, including motor and cognitive improvements in an open-label phase 2 study [161] which persisted 12 months after drug withdrawal [162], as well as motor improvement in a placebo-controlled phase 2 trial [163]
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