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Retatrutide is the first medication to mimic three hormones, GLP-1, GIP and glucagon, rather than the one or two that current medications use

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The review highlights recent advancements in the formulation of melittin, such as transdermal patches, microneedle-delivered gels, and nanoemulsion-based topical applications, which may enhance its therapeutic delivery and minimize adverse effects

Warning signs include severe, persistent abdominal pain that radiates to the back, nausea and vomiting that do not resolve, and tenderness in the upper abdomen