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doi:10.1007/978-3-319 -50520-6_10
A 12-week randomized trial demonstrated: Average weight loss of 2.6 kg in AOD-9604 group (1 mg/day) versus 0.8 kg in placebo group Preferential reduction in abdominal and visceral fat deposits No adverse effects on carbohydrate metabolism or insulin sensitivity Non-dose-dependent effects, with higher doses (10 mg/day) producing less weight loss than lower doses However, a subsequent 24-week Phase III trial with 502 subjects incorporating intensive diet and exercise showed no statistically significant weight loss compared to placebo, leading to development termination in 2007
16 Although accumulating evidence demonstrated success in controlling TACE-related pain could reduce opioid analgesic use and improve patient quality of life, there is still considerable heterogeneity in drug selection and the associated duration of action and route of administration
According to the World Health Organization, 39% of adults worldwide are overweight, and the most effective approach combines multiple strategies
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