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In brain ischemiareperfusion injury, using PARP-1 inhibitors (such as PJ-34, Olaparib) can mitigate H 2 O 2 /O/OH accumulation, prevent neuronal damage, and enhance neurological recovery [253]

The monitoring of GSH/GSSG ratio and the quantification of GSSG in biological samples are essential for evaluating the redox and detoxification status of cells and tissues in relation to the protective role of glutathione against oxidative and free-radical-mediated cell injury

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