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Blocking the animals oxytocin receptors inhibits their pair bonding, but administering oxytocin leads to bonding without mating, a 1995 study found

The peptide also stimulates oxytocin release from hypothalamic neurons, contributing to its effects on social behavior and bonding

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The hepatic extraction ratio refers to the fraction of drug removed from the blood on a single pass through the liver, a value which is equal to 1-f H