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Second, elevated lactate directly inhibits immune cell activation/proliferation and drives Kla-mediated immunosuppression, promoting CTLA-4 expression in T cells, M2-like macrophage polarization, and dendritic cell dysfunction (47)

That's the heart of the gutGLP-1 axis: fermentable fiber becomes short-chain fatty acids, SCFAs signal through FFAR2 and FFAR3, and your body's own appetite and glucose hormones respond

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