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Together, these data demonstrate that GLP-1R signaling increases both DAT expression at the plasma membrane and DA uptake, suggesting that GLP-1R signaling might regulate cocaine actions in the LS through DAT-dependent mechanisms

They also signal in key brain areas involved in appetite, motivation, and reward

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Zhang Q, Pan R, Han L, Shi C, Kurtz S, Mu H, Ma H, Andreeff M , Leverson J, Mi Y, Tyner JW, Konopleva M

Results Cystine availability regulates mTORC1 signaling and the ISR We studied the effect of cystine starvation in HepG2 cells, which do not synthesize cysteine from methionine, to exclude the confounding effect of methionine 20