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Of note, Kovac et al

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In cases where operation is not possible, simultaneous chemo-radiotherapy is the standard of care, while neoadjuvant chemotherapy is common in operable patients [126]

Yet this compelling mechanistic story has generated precisely zero human clinical trials for mental health applications

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Typical approaches include ultrafiltration, size-exclusion chromatography (SEC), dialysis, centrifugation, and analytical quantification by HPLC, LC-MS, or UV spectroscopy