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Thus, while each platform has demonstrated proof-of-concept efficacy, the choice of design must balance responsiveness, stability, and biosafety to ensure clinical applicability

No significant correlation was found between metabolite levels and hyper/impulsive scores of ADHD, measures of core ASD symptoms (ADOS-2, SRS-P) or adaptive behavior (ABAS-2)

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In these cases, lifestyle changes or targeted therapies may be needed to restore the balance

The natural history of the active phase is discussed, demonstrating that most patients experience progression or stability rather than spontaneous improvement

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