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We explain in this review, using the current scientific literature to inform our assessment
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Collectively, these mechanisms encompassing PI3K/Akt activation, modulation of Sirt1-Foxo1, reduction of oxidative stress, inhibition of apoptosis, and cholinergic receptor-mediated anti-inflammatory effects, provide a robust biological basis for curcumins neuroprotective and cytoprotective effects in PD (Nebrisi, 2021)
Orlistat, for instance, works by blocking the absorption of dietary fats in the digestive system, but its side effects, such as gastrointestinal discomfort, often make it difficult for patients to stick with the treatment
Gradual dose changes instead of abrupt stops
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