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Samples (whole cells or isolated mitochondria) were freeze-thawed three times, and the lysates filtered through 10-kDa molecular mass cutoff devices (Amicon, Millipore) at 12,000 g for 15 min at 4 C

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Clinical data from the SURMOUNT trials demonstrated that patients using tirzepatide lost between 16% and 22% of their starting body weight depending on their dose level and adherence

Interplay between lipid dysregulation and ferroptosis in chondrocytes and the targeted therapy effect of Metformin on osteoarthritis