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The time-to-onset interval was subsequently computed as the temporal difference between EVENT_DT (the recorded date of adverse event manifestation) and START_DT (the documented date of therapeutic intervention initiation)

Similarly, the expression of multidrug resistance-associated protein 2 can reduce intracellular cisplatin levels by effluxing the drug, thereby diminishing its efficacy (60)

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308 However, possible side effects of PEG are bloating and abdominal pain, and dosing should be gradually increased to help lessen their likelihood

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