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When using the calculator is the volume at the bottom the amount you draw up in the syringe

10.1038/s41589-018-0031-6 49 GaschlerM

Not only can you taste the difference, but you can actually feel the difference when you use Phormula-1

The aqueous medium serves as a pool where protons can be parked when the transfer reaction is solely of electrons (the analogy borrowed from the very accessible introductory biochemistry book The chemistry of life by Steven Rose)

10.1016/j.tips.2024.04.012 130 OwenM

Clinical experience strongly supports its use for the indications below but we're working with promising preclinical data, not robust human RCTs